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Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (title Beforehand used: bishydroxycoumarin) and causes a decrease in anticoagulant action as calculated with the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting in amplified metabolism and lessened anticoagulant reaction of oral anticoagulants (e. Ov